James Foley

Photochemistry and Photobiology


Rowland Senior Fellow
Rowland Institute at Harvard
Harvard University
100 Edwin H. Land Blvd.
Cambridge, MA 02142
Tel: 617-497-4677
Fax: 617-497-4627
Email: foley@rowland.harvard.edu
Website:Photochemistry and Photobiology 

Our research interests center on understanding fundamental structure/function relationships pertaining to the photophysics that govern the properties and behavior of organic dyes. We use this knowledge to develop improved chromophores for use in biophysical, biological and medical applications such as single molecule detection, fluorescent reporting and photodynamic therapy. Our approach encompasses nearly every aspect that is essential to such an undertaking including computer-aided design, chemical synthesis and photophysical characterization of target dyes.

Selected Publications

  • Song, Xiangzhi; Johnson, Alexis; Foley, James. "7-Azabicyclo[2.2.1]heptane as a unique and effective dialkylamino auxochrome moiety: Demonstration in a fluorescent rhodamine dye." Journal of the American Chemical Society, 130(52), 17652-17653 (2008).
  • Song, Xiangzhi; Kassaye, Daniel S.; Foley, James W.. "5,9-Diaminodibenzo[a,j]-phenoxazinium Chloride: A Rediscovered Efficient Long Wavelength Fluorescent Dye." Journal of Fluorescence, 18(2), 513-518 (2008).
  • Foley, James W.; Song, Xiangzhi; Demidova, Tatiana N.; Jilal, Fatima; Hamblin, Michael R., "Synthesis and Properties of Benzo[a]phenoxazinium Chalcogen Analogues as Novel Broad-Spectrum Antimicrobial Photosensitizers". Journal of Medicinal Chemistry, 49(17), 5291-5299 2006).
  • Nikas, D.C.; Foley, J.W.; Black, P.M., "Fluorescent Imaging in a Glioma Model in Vivo," Lasers Surg Med 29, 11-17 (2001).
  • Frimberger, A.E.; Moore, A.S.; Cincotta, L.; Cotter, S.M.; Foley, J.W., "Photodynamic therapy of naturally occuring tumors in animals using a novel benzophenothiazine photosensitizer", Clinical Cancer Research, 4, 2207-2218, (1998).

For a complete list of publications.