Ethan Schonbrun

Optofluidic Cytometry 

Rowland Junior Fellow
Rowland Institute at Harvard
Harvard University
100 Edwin H. Land Blvd.
Cambridge, MA 02142
Tel: 617-497-4xxx
Fax: 617-497-4627
Website:href=""> Optofluidic Cytometry Lab

In biotechnology and medical diagnostics there is a large demand for the analysis of enormous sets of samples. Optical detection systems such as micro-array scanners, flow cytometers, and fluorescence microscopes are the standard work horse instrumentation for these applications. While these systems have proven successful, they are frequently based on the frame of a standard optical microscope which has tradeoffs in field of view, resolution, and light collection. By designing optical systems using a priori knowledge of the sample, many of these tradeoffs can be circumvented. In the MOIRE lab, we will investigate optical detection systems based on microfabricated components, such as lens arrays, computer generated holograms, and artificial dielectrics. By integrating these components with microfluidics and high speed cameras, we hope to realize a new generation of optical diagnostic devices.

Selected Publications

  • E. Schonbrun, A. R. Abate, P. Steinvurzel, D. A. Weitz, and K. B. Crozier, "High throughput fluorescence detection using an integrated zone plate array," Lab Chip, 10, 852 (2010).

  • E. Schonbrun, W. N. Ye, and K. B. Crozier, "Scanning microscopy using a short-focal-length Fresnel zone plate," Opt. Lett. 34, 2228 (2009).

  • E. Schonbrun, J. Wong, and K. B. Crozier, "Co- and cross-flow extensions in an elliptical optical trap," Phys. Rev. E. 79, 042401 (2009) .

  • E. Schonbrun and K. B. Crozier, "Spring constant modulation in a zone plate tweezer using linear polarization," Opt. Lett. 33, 2017 (2008).