SJ Claire Hur

µFluidic Biophysics Lab



Rowland Junior Fellow
Rowland Institute at Harvard
Harvard University
100 Edwin H. Land Blvd.
Cambridge, MA 02142
Tel: 617-497-4713 
Fax: 617-497-4627
Email: hur@rowland.harvard.edu
Website: µFluidic Biophysics Lab

Single-cell deformability has been recently identified as a critical biomarker for various diseases and it varies considerably based on phenotypes. Current cell deformability measurement techniques, however, are inherently low throughput for statistical analysis of large heterogeneous biological samples. We focus on developing high-throughput microfluidic techniques for measuring intrinsic properties of single cells, including intracellular viscosity, membrane tension/elasticity and Young's modulus. These measurements will allow us to identify potential genetic-alterations and phenotype-changes, responsible for modification in such properties of cells. Furthermore, systematic determination of single-cell mechanical properties in a rapid and standardized manner will expedite an adoption of aforementioned properties as new types of biomarkers for phenotype characterizations. These newly revealed biomarkers should provide efficient tools for determining the cell state and phenotype, which are potentially useful for cancer diagnostics and prognostics, cell-based therapeutics as well as developmental biology.

Selected Publications

  • SJ. Claire Hur, Sung-Eun Choi, Sunghoon Kwon and Dino Di Carlo, "Inertial focusing of non-spherical microparticles", Applied Physics Letters, 99, 044101[Link]

  • SJ. Claire Hur, Albert J. Mach and Dino Di Carlo, "High-throughput size based rare cell enrichment using microscale vortices", Biomicrofluidics, 2011, 5, 022206 (Selected and featured in Virtual Journal of Biological Physics Research, Vol. 22, Issue 1) [Link]

  • SJ. Claire Hur, Nicole K. Henderson-MacLennan, Edward R.B. McCabe and Dino Di Carlo, "Deformability-based cell classification and enrichment using inertial microfluidics", Lab on a Chip, 2011, 11, 912-920 (Highlighted in Research Highlights in Lab on a Chip, DOI:10.1039/C1LC90074A ) [Link]

  • SJ. Claire Hur, Henry T.K. Tse and Dino Di Carlo, "Sheathless inertial cell ordering for extreme throughput flow cytometry", Lab on a Chip, 2010,10, 274-280 (Selected as Cover Page Article, Highlighted in Chemical Biology News) [Link]